Antibodies to Self-Antigens Predispose to Primary Lung Allograft Dysfunction and Chronic Rejection
نویسندگان
چکیده
منابع مشابه
Role of antibodies to self-antigens in chronic allograft rejection: potential mechanism and therapeutic implications.
Significant progress has been made in preventing acute allograft rejection following solid organ transplantation resulting in improved allograft survival. However, long term function still remains disappointing primarily due to chronic allograft rejection. Alloimmune responses primarily defined by the development of antibodies (Abs) to donor mismatched major histocompatibility antigens during t...
متن کاملAcute and Chronic Lung Allograft Rejection
Over the last decade, lung transplantation has become a 'viable option for patients with end-stage lung disease. Due to the relatively small number of lung transplants done nationally, little experience has been gained in the outcome and management of pregnancies in the post-lung transplant patient, and little published data exist to assist the patient's physician regarding issues related to pr...
متن کاملChronic lung allograft rejection: mechanisms and therapy.
Lung transplantation is a therapeutic option for patients with end-stage pulmonary disorders. Unfortunately, due to post-lung transplant complications, both infectious and noninfectious, it is only a treatment and not a cure. Importantly, despite induction combined with triple or quadruple maintenance immunosuppressive therapy, chronic lung rejection, in the form of obliterative bronchiolitis o...
متن کاملPhysiology of chronic lung allograft dysfunction: back to the future?
Chronic lung allograft dysfunction (CLAD) is, in one sense, a term without a true consensus definition, although its common usage in the field of lung transplantation implies a base understanding throughout the community that it describes a lung allograft that does not work (well) [1]. There appears to be general agreement that CLAD most commonly occurs in a time-dependent fashion after transpl...
متن کاملChronic lung allograft dysfunction: evolving practice.
PURPOSE OF REVIEW Chronic lung allograft dysfunction (CLAD) was recently introduced as an overarching term covering different phenotypes of chronic allograft dysfunction, including obstructive CLAD (bronchiolitis obliterans syndrome), restrictive CLAD (restrictive allograft syndrome) and graft dysfunction due to causes not related to chronic rejection. In the present review, we will highlight t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Annals of Thoracic Surgery
سال: 2010
ISSN: 0003-4975
DOI: 10.1016/j.athoracsur.2010.06.009